苁蓉益肾颗粒治疗非痴呆型血管性认知损害病人60例临床观察

摘要

目的：观察苁蓉益肾颗粒治疗非痴呆型血管性认知损害的临床疗效。方法60例病人随机分为治疗组和对照组，每组30例。在给予血管治疗的基础上，治疗组同时加用苁蓉益肾颗粒，对照组加用茴拉西坦片。2组疗程均为6月，观察2组简易智能精神状态检查量表（ MMSE）、蒙特利尔认知评估量表（ MoCA）、日常生活活动量表（ ADL）及中医痴呆证候量表评分变化情况。结果治疗后治疗组和对照组的MMSE和MoCA量表的评分均有提高，中医症候积分降低，与本组治疗前比较，差异均有统计学意义（ P＜0.05或P＜0.01）。苁蓉益肾颗粒在中医症候积分、MMSE评分方面改善较茴拉西坦明显，差异有统计学意义（ P＜0.01）。2组病人血、尿、粪常规，肝、肾功能及心电图等指标治疗前后均正常。结论苁蓉益肾颗粒对血管性认知损害非痴呆型病人的疗效肯定。%Objective To observe the therapeutic effect of cong-rong-yi-shen granule for the patients with vascular cognitive impairment with no dementia( VCIND) . Methods Sixty VCIND patients were randomized into control group and treatment group with 30 cases in each group. On the basis of the treatment targeting risk factors of blood vessels,patients in the treatment group were treated with cong-rong-yi-shen granule,while those in the control group were treated with Aniracetam. The therapeutic course was six months. The clinical effect was observed through mini-mental state examination ( MMSE ) , Montreal cognitive assessment(MoCA),activities of daily living(ADL), scores of Chinese medical symptoms before and after the treatment. Results After the treatment, the scores of MMSE, MoCA were significantly increased,while the scores of Chinese medical symptoms decreased in both groups(P<0. 05 or P<0. 01). Treatment group showed obvious effects in the score of MMSE and scores of Chinese medical symptoms compared with control group. There was no significant difference in blood routine,urine,stool routine,liver function,renal function and cardiogram after the treatment in both groups. Conclusions Cong-rong-yi-shen granule is effective for VCIND.