Oxygen-Ozone Autohaemotherapy and Intravescical Oxygen-Ozone Insufflations in Treatment of Recurrent and Interstitial Cystitis： Preliminary Results

摘要

Introduction： Cystitis has high incidence in female population. Inflammation is responsible of irritative symptoms; it issupposed the existence of an arterial obstructive disease connected with bladder ischaemia. Direct bacterial damage and/orinflammation are responsible of the activation of ROS （radicals of oxygen） and consequent cell damage. NF-kB protein is protagonistin ROS synthesis. High levels of 02 in periphereal tissues reduce ischaemia, responsible of recurrent inflammation and increaseantioxidant effects in presence of controlled oxidation. The aim of this study is the essay of anti-inflammatory effects of OOT（oxygen-ozone therapy） in chronic cystitis, employed in combined subministration. OOT properties could decrease bacterialconcentration and eliminate dysuriac disturbances, reducing ischaemic effects. Methods： This study proposes a combined treatment forcystitis with oxygen-ozone AHTM （autohaemotherapy） and intravescical insufflations. It has been selected 8 Women aged 40-55 yearswith recurrent cystitis, associated with pain and urge incontinence. We have used certified medical OOT generator. Results： Aftertherapies, all patients showed sterile urine and progressive reduction of symptoms with a sensible improvement of quality of life.Conclusions： Nevertheless, in a little group of patients, preliminary results could suggest the use of OOT for recurrent cystitis afterfailure of conventional therapies.