槟榔中与烯丙基焦儿茶酚具有协同抗疟疾作用化合物的生物活性导向分离

摘要

Objective:To screen out the principles possessing the anti-malaria synergistie effect with allylpyrocatechol from Semen Arecae.Meth-od:Bioassay guided isolation wR8 used to find out the monomeric compounds by carrying out the vitro anti-malaria assay on the fractions isola-ted from the MeOH extract of Semen Arecae.Results:Two compounds were screened out and showed the moderate synergistic effect of vitro anti-malaria activities with allylpyroeatechol under the concentration in which all of them showed very weak anti-malaria activities when they were used alone.%目的:从槟榔中筛选出能与烯丙基焦儿茶酚具有协同抗疟疾的化合物.方法:运用生物活性导向分离的方法,把从槟榔的甲醇提取物中分离的各组分进行体外抗疟疾试验,找出活性单体.结果:筛选出能与烯丙基焦儿茶酚具有协同抗疟疾作用的两个化合物,他们与烯丙基焦儿荼酚在一定浓度下单独给药体外抗疟疾效果很盖.但是联合给药具有较好的体外协同抗疟痰作用.