Tumor-targeted niosome as novel carrier for intravenous administration of tocotrienol

摘要

Tocotrienol(T3),the unsaturated form of vitamin E,has gained global attention due to its potent anticancer effects against a wide range of cancers.Found abundantly in palm oil[1],T3was reported to exhibit their anti-cancer properties via various pathways including anti-proliferative,anti-angiogenesis,antiinflammatory,apoptosis and improvement of immunological function[2].However,the lack of tumor specificity and rapid body clearance have restricted the clinical applications of T3[3].