两种水化疗法预防造影剂诱发肾病的效果比较

摘要

Objective: To compare the effect of two kinds of hydration therapy in prevention of contrast-induced nephropathy (CIN). Methods: Totally 120 patients were enrolled in this study. They were divided randomly into the sodium chloride treated group(n=60) and the sodium bicarbonate treated group(n=60). The levels of serum creatinine, blood urine nitrogen and urine β2 -microglobulin were measured at any time three days before and at day three and seven after coronary angiograph. The incidences of CIN in the two groups were analyzed. Results: The incidence of CIN in the sodium bicarbonate treated group was significantly lower than that in the sodium chloride treated group (P0.05). Conclusions: Hydration with sodium bicarbonate before contrast exposure is more effective than hydration with sodium chloride in the prevention of CIN.%目的:比较两种水化疗法对造影剂肾病(contrast-induced nephropathy,CIN)的预防效果.方法:将120例患者随机分为氯化钠水化组(60例)和碳酸氢钠水化组(60例),检测患者造影前3天内及造影后第3天、7天的血肌酐、尿素氮和尿β2微球蛋白.分析两组患者CIN的发病率.结果:造影后第3天碳酸氢钠水化组CIN的发病率显著低于氯化钠水化组(p＜0.05),7天两水化组间CIN的发病率无明显差异(P＞0.05).提示两种水化疗法对CIN的预防效果相仿.结论:对于造影剂引发的急性肾损伤,在造影前采用碳酸氢钠进行水化预防比采用氯化钠水化预防更有效.