儿童器官捐献供肾肾移植疗效的临床研究

摘要

目的：探讨儿童器官捐献供肾移植的近期临床疗效。方法回顾性分析2013年11月至2015年12月西安交通大学第一附属医院肾移植科完成的15例儿童器官捐献供者，供给28例肾移植受者（其中双肾移植2例）的供、受者临床资料。结果28例受者手术均获成功。移植肾热缺血时间中位数为12.5 min （0～17.0 min），冷缺血时间中位数为4.3 h （1.5～7.7 h）。术后出现移植物功能延迟恢复（DGF）4例、透析1例、因肺部感染死亡2例、肾吻合口狭窄和供肾血栓形成后切除移植肾各1例。术后随访1～24个月，受者存活26例（93％），带肾存活受者24例（86％），其移植肾功能均正常。结论儿童器官捐献供者双肾整块移植及单肾移植早期临床疗效较好。%Objective To evaluate short-term clinical efficacy of renal transplantation from the donation of pediatric donors.Methods Clinical data of 1 5 pediatric donors and 28 recipients (including 2 cases of bilateral renal transplantation)undergoing renal transplantation in the Department of Renal Transplantation of the First Affiliated Hospital of Xi'an Jiaotong University from November 201 3 to December 201 5 were retrospectively analyzed. Results Renal transplantation was successfully performed in 28 recipients.The median warm ischemia time of transplant kidney was 1 2.5 min (range:0-1 7.0 min)and 4.3 h (range:1 .5-7.7 h)for the median cold ischemia time.After operation,4 cases developed with delayed graft function (DGF),1 required dialysis,2 died from pulmonary infection,2 underwent renal resection due to renal anastomosis stenosis and renal thrombosis.Postoperative follow-up lasted for 1 -24 months.Twenty-six (93%)recipients survived after renal transplantation and 24 (86%)recipients survived with restored normal renal function.Conclusions Unilateral and bilateral renal transplantation from pediatric donors has relatively favorable short-term clinical efficacy.