热疗联合FOLFOX6方案治疗晚期结直肠癌疗效观察

摘要

Objective To observe the efficacy and adverse reactions of thermotherapy combined with FOLFOX6 chemotherapy for advanced colorectal cancer. Methods 79 patients with advanced colorectal cancer were randomly divided into two groups. Treatment groups received FOLFOX6 systemic chemotherapy combined with thermotherapy; FOLFOX6 regiment was as follows; oxaliplatin 100 mg/m2 ivgtt 3h dl , leucovorin 100 mg ivgtt 2h dl , 5-fluorouracil 400mg/m2 iv dl, 5- flu-orouracil 2000 mg/m2 civ 46h. Treatment groups received thermotherapy at local tumor, twice a cycle. Control groups received only FOLFOX6 systemic chemotherapy. Results In treatment groups, 22 cases achieved PR, 8 cases achieved SD. The RR, DCR and PFS were 59. 46% , 81. 08% and 8. 2 months, respectively. While in control groups, 14 cases achieved PR, 11 cases achieved SD. And the RR, DCR and PFS were 33. 33% , 59. 52% and 5. 3 months, respeetively. So treatment group was superior to control group in the above three parameters (P < 0. 05). Conclusion Thermotherapy combined with FOLFOX6 systemic chemotherapy is safe and effective for patients with advanced colorectal cancer.%目的 观察热疗联合FOLFOX6方案治疗晚期结直肠癌的疗效和不良反应.方法 79例晚期结直肠癌患者随机分为两组,治疗组(热疗联合化疗)采用(FOLFOX6):奥沙利铂100 mg/m2静滴d1、亚叶酸钙100mg静滴2小时d1、氟尿嘧啶400 mg/m2静推d1、氟尿嘧啶2000 mg/m2持续泵入46小时,14天为一个周期.热疗针对复发转移肿瘤部位,每个化疗周期两次热疗.对照组仅采用FOLFOX6方案化疗.结果 治疗组PR 22例,SD 8例,PD7例,有效率(RR) 59.46％,疾病控制率(DCR) 81.08％,无进展生存期(PFS) 8.2个月.对照组PR 14例,SD 11例,PD 17例,有效率(RR) 33.33％,疾病控制率(DCR) 59.52％,无进展生存期(PFS) 5.3个月.治疗组在有效率、疾病无进展生存期、疾病控制率等方面优于对照组(P＜0.05),且不增加毒副反应.结论 热疗联合FOLFOX6方案治疗晚期结直肠癌疗效较好,不良反应能耐受.