血清CRP、CA72-4水平变化与结直肠癌发生发展的关系

摘要

目的 探讨C反应蛋白(CRP)、肿瘤上皮来源相关抗原(CA72-4)水平与结直肠癌发生发展的关系.方法 选取250例结直肠癌患者为结直肠癌组,选取250例结肠息肉患者为结肠息肉组,对两组患者的临床资料进行回顾性分析.观察比较两组患者的血清CRP、CA72-4水平,并对不同临床病理特征结直肠癌患者的CRP、CA72-4水平进行比较,分析影响结直肠癌患者血清CRP、CA72-4水平的因素.结果 结直肠癌组患者的血清血清CRP、CA72-4水平均明显高于结肠息肉组(P﹤0.001);年龄≥65岁、有淋巴结转移、组织学分型为管腺癌、TNM分期为Ⅲ~Ⅳ期、肿瘤直径≥5 cm的结直肠癌患者的血清CRP、CA72-4水平均明显高于年龄﹤65岁、无淋巴结转移、组织学分型为黏液腺癌、TNM分期为Ⅰ~Ⅱ期、肿瘤直径﹤5 cm的患者(P﹤0.001);淋巴结转移、TNM分期是影响结直肠癌患者血清CRP、CA72-4水平的因素.结论 结直肠癌患者的血清CRP、CA72-4水平较高,且与患者的淋巴结转移情况和TNM分期密切相关.%Objective To investigate the correlation between CRP and CA72-4 levels and the occurrence and develop-ment of colorectal cancer. Method The clinical data of patients with colorectal cancer (n=250) or colon polyps (n=250) were retrospectively analyzed. The level of serum CRP and CA72-4 of the two groups were observed, and were further compared in colorectal cancer patients with different clinicopathological features, the factors affecting CRP and CA72-4 levels were analyzed. Result The levels of CRP and CA72-4 in patients with colorectal cancer were significantly higher than those in control group (P<0.001);patients aged≥65 years old, with lymph node metastases, histological type of duc-tal adenocarcinoma, TNM stage Ⅲ-Ⅳ, and tumor diameter≥5 cm had higher level of serum serum CRP and CA72-4 than those with age<65, no lymph node metastasis, histological type of mucinous adenocarcinoma, TNM stage Ⅰ-Ⅱ, and tumor diameter < 5 cm (P<0.001); lymph node metastasis and TNM stage were factors influencing the level of serum CRP and CA72-4 in patients with colorectal cancer. Conclusion The level of serum CRP and CA72-4 are high in pa-tients with colorectal cancer, and is closely related to the lymph node metastasis and TNM stage.