Improving the detecting efficiency of suspected gastrointestinal tumors with dual-time-point 18F-FDG PET/CT

摘要

We conducted a retrospective analysis of 221 subjects with 256 suspected gastrointestinal lesions from2007 to 2015 to explore the detecting efficiency of dualtime-point fluorine-18 fludeoxyglucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT)and pathology examination. The abdominal delayed PET/CT was performed within 45 min of the conventional scan.The change in maximum standardized uptake value(ASUV_(max)) and morphological features of the suspected lesions between the conventional and dual-time-point PET/CT were compared. The sensitivity, specificity, positive predictive value, and negative predictive value(NPV) of conventional PET/CT were 81.6%(84/103), 56.2%(86/153), 55.6%(84/151), and 81.9%(86/105), respectively.Those of dual-time-point PET/CT were 94.1%(97/103),78.4%(120/153), 74.6%(97/130), and 95.2%(120/126),respectively. There was a significant difference between the conventional and dual-time-point PET/CT(P < 0.005).The SUV_(early) and the %△SUV_(max) could not present more information in differential diagnoses, but the rate of tumors with increased SUVdelay accounted for 79.6%(82/103) and more than that of nonneoplastic lesions(15.5%, 29/187)(x^2= 115.5, P < 0.01). Therefore, the dual-time-point^(18)F-FDG PET/CT had a higher sensitivity and NPV than the conventional PET/CT to detect gastrointestinal tumors.The constant morphology and increased SUV_(delay) help to detect the tumors and adding delayed imaging on the locality will be an effective method when we accidentally find a suspected gastrointestinal tumor on the conventional PET/CT images.