The dose calculation parameters of I03Pd radioactive seed need to be determined strictly before clinical application for tumor implanted treatment. The radial dose function and the anisotropy factor are data analyzed and nonlinear fitted based on the value of dose parameters in American Association of Physicists in Medicine ( AAPM) TG -43 and TG -43U1 by Cftool and SFTool toolbox in Matlab. Result was selected according to the optimum principle of fitting accuracy that is the coefficient of determination is close to 1 and gets the minimum value of the sum of square of deviations in fitting process. The calculation of the radial dose function and the anisotropy factor result are obtained in an ideal situation, and then the dose calculation of 103Pd radioactive seed is determined. The calculation of 103Pd radioactive seed provides a theoretical basis for 103Pd implanted treatment of tumor in clinical.%临床使用放射性籽源对肿瘤进行植入治疗之前,需要对籽源的剂量参数进行严格确定.依据AAPM TG-43报告[1～2]给出的剂量计算参数值,利用matlab工具中的cftool及SFTol工具箱分别对径向剂量函数和各向异性函数进行数据分析和非线性拟合.在拟合的过程中,按照拟合精度最优化,即确定系数(R2)最接近1、偏差平方和(SSE)最小的原则,筛选出最优的拟合结果.最终分别得到了径向剂量函数和各向异性函数的最优计算方法,从而得到103pd放射性籽源的剂量率计算模式.103Pd放射性籽源的剂量率计算模式,为103Pd放射性籽源对肿瘤进行植入治疗提供了理论上的剂量学依据.
展开▼
