Neural regeneration is a great clinical challenge in both the central nervous system(CNS)and the peripheral nervous system(PNS).Degeneration in the CNS caused by disease(such as Alzheimer's or Parkinson's diseases)or trauma(such as traumatic brain injury and spinal cord injury)often results in permanent paralysis and loss of sensation.The spontaneous neural regeneration in the CNS is generally unsuccessful,while the PNS has an intrinsic regenerative ability.However,PNS regeneration occurs over relatively short distances.Damage to the PNS results in the motor and cognitive impairment in many cases.Biomaterials in the form of scaffolds or nanoparticles for neuroprotection and neuroregeneration have attracted much attention.Nanoparticles can be fabricated using various lioids.
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