Understanding metabolic flexibility: a potential key to unlocking metabolic therapies in amyotrophic lateral sclerosis?

摘要

The role of metabolism in amyotrophic lateral sclerosis(ALS):ALS,is a predominantly sporadic,neurological disorder resulting in degeneration of both upper and lower motor neurons,resulting in the progressive failure of the neuromuscular system.The lifetime risk factor for developing ALS sits between 1 in 300 and 1 in 400.However,due to the speed of the disease course(2–3 years post-diagnosis)and the lack of effective therapies,ALS is still classified as a rare disease.