Effects of electroacupuncture on microcirculatory blood flow and glucose transporter function in the hippocampus

摘要

Nerve cell metabolism in post brain ischemia depends on increased microcirculation perfusion and transport function of microvascular endothelial cells.In the present study,a rat model of middle cerebral artery occlusion was established to investigate the influence of electroacupuncture(EA) on hippocampal CA1 cerebral blood flow and glucose transporter 1(GLUT1) expression in the microvascular endothelial cells.Following EA at Neiguan(PC 6),the cerebral blood flow in the ischemic hippocampal CA1 region was significantly elevated,the number and microvascular integrated absorbance of the GLUT1-positive cells were significantly increased,nerve cell damage was ameliorated,and GLUT1 protein expression in the ischemic hippocampus was significantly increased.Results demonstrate that EA increased the cerebral blood flow of the hippocampal CA1 region and improved the glucose transport function,thereby attenuating neuronal injuries.