Analyzing the role of extracellular matrix during nervous system development to advance new regenerative strategies

摘要

Regeneration in the central nervous system(CNS)is limited,and CNS damage often leads to cognitive impairment or permanent functional motor and sensory loss.Impaired regenerative capacity is multifactorial and includes inflammation,loss of the bloodbrain barrier,and alteration in the extracellular matrix(ECM).One of the main problems is the formation of a glial scar and the production of inhibitory ECM,such as proteoglycans。