一株马兜铃内生真菌Colletotrichum sp.代谢产物中细胞毒活性成分的研究

摘要

从马兜铃内生真菌Colletotrichum sp.的大米发酵产物中分离得到6个化合物,经波谱数据分析分别鉴定为7 -hydroxy-10 -oxodehydrodihydrobotrydial(1)、格链孢酚(2)、5-甲氧基格链孢酚(3)、链格孢毒素I(4)、腾毒素(5)和二氢腾毒素(6).以上化合物均为从该菌属中首次分离得到,其中化合物1～4对肺癌细胞和乳腺癌细胞有一定的细胞毒活性.%Six compounds were isolated from the fermented rice substrate of endophytic fungus CoUetotrichum sp. Isolated from Aristolochia spp. In Zhejiang Province. They were identified as 7-hydroxy-l0-oxodehydrodihydrobotrydial (1) ,alter-nariol (2),alternariol 5-0-methyl ether (3) ,altertoxin I (4), tentoxin (5) ,and dihydrotentoxin (6) on the basis of spectroscopic data analyses. All the compounds were firstly isolated from CoUetotrichum sp. , among which compounds 1-4 showed cytotoxic activity against both lung cancer cell line A549 and breast cancer cell line MDA-MB-231.