首页> 外文期刊>纳米研究(英文版) >Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells
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Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells

机译:具有光触发药物递送功能的碳酸钙-阿霉素@二氧化硅-吲哚菁绿色纳米球增强对耐药性乳腺癌细胞的杀伤力

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摘要

Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized,in order to provide a photo-triggered strategy for drug-resistant cancer therapy.Under near-infrared laser irradiation,the nanospheres transformed laser power into local heat and reactive oxygen species via the connected indocyanine green molecule,thus exhibiting photothermal and photodynamic effects.Moreover,the photo-triggered drug release based on calcium-assisted silica degradation was observed,endowing the nanospheres with chemotherapeutic properties.Finally,combined therapeutic effects against drug-resistant human breast cancer cells were successfully obtained.These photo-triggered materials based on calcium carbonate could provide a promising platform for enhanced multimodal cancer therapies.
机译:设计并合成了具有高均匀度和单分散性的碳酸钙-阿霉素@二氧化硅-吲哚菁绿色纳米球,以提供一种用于光触发的耐药癌症治疗策略。在近红外激光照射下,纳米球将激光功率转化为局部通过连接的吲哚菁绿分子产生热和活性氧,从而表现出光热和光动力效应。此外,观察到基于钙辅助二氧化硅降解的光触发药物释放,赋予了纳米球化学治疗性能。最后,对纳米球具有综合治疗作用成功地获得了具有抗药性的人乳腺癌细胞。这些基于碳酸钙的光触发材料可以为增强多模式癌症治疗提供有希望的平台。

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  • 来源
    《纳米研究(英文版)》 |2018年第6期|3385-3395|共11页
  • 作者单位

    Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China;

    Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China;

    Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China;

    Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China;

    School of Chemistry and Chemical Engineering, Hefei University of Technology, Hefei 230009, China;

    Division of Nanomaterials & Chemistry, Hefei National Research Center for Physical Sciences at the Microscale, Collaborative Innovation Center of Suzhou Nano Science and Technology, Department of Chemistry, CAS Centre for Excellence in Nanoscience, Hefei Science Centre of CAS, University of Science and Technology of China, Hefei 230026, China;

  • 收录信息 中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
  • 原文格式 PDF
  • 正文语种 eng
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  • 入库时间 2022-08-19 03:47:27
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