雷公藤、白芍总苷、苦杏仁水煎剂对佐剂型关节炎大鼠治疗效果及机制的比较

摘要

目的 比较雷公藤、白芍总苷、苦杏仁水煎剂对佐剂性关节炎(AA)大鼠模型抗炎作用效果及机制差异,为类风湿关节炎的防治提供理论依据.方法 建立AA大鼠模型,比较雷公藤、白芍总苷、苦杏仁水煎剂对AA大鼠足踝关节组织病理及血清中促炎因子肿瘤坏死因子α(TNF-α)、免疫细胞间黏附分子(sICAM-1)水平的影响.结果 雷公藤、白芍总苷、苦杏仁水煎剂均能有效抑制关节肿胀,减轻炎症的发展,并降低AA大鼠血清中TNF-α、sICAM-1的水平.与雷公藤相比,白芍总苷、苦杏仁水煎剂更能降低血清中TNF-α的水平.结论 雷公藤、白芍总苷、苦杏仁水煎剂均可起到抗类风湿关节炎作用,白芍总苷、苦杏仁水煎剂可有效降低血清中TNF-α的水平.%Objective It is to compare the anti-inflammatory effect and mechanism on the adjuvant arthritis( AA ) rat model by three traditional Chinese medicine Tripterygium, total glucosides of paeony ( TGP )and Apricot Kernel, and to provide theoretical basement for the prevention and treatment of rheumatoid arthritis. Methods After establishing A A rat models, the effects of Tripterygium, TGP and Apricot Kerne on pathology of anklebone and levels of sICAM - 1 and TNF - a were compared. Results Tripterygium, TGP and Apricot Kerne all could effectively inhibit swelling of points and development of inflammatory, and could decrease the level of sICAM - 1 and TNF - a in the serum of AA rats. Compared with Tripterygium, TGP and Apricot Kernel can more significantly decrease the level of TNF - a. Conclusion Tripterygium, TGP and Apricot Kernel has good antiarthritic effects, TGP and Apricot Kernel can significantly decrease the level of serum TNF - a.