象皮生肌膏对大鼠肛瘘创面修复中TGF－β1表达的影响

摘要

Objective It is to discusses the mechanism of Xiangpi ShengJi ointment in the wound repair of anal fistula . Methods 30 SD rats were selected to establish the models of postoperative wound of anal fistula , then they were randomly di-vided into 3 groups , respectively as Xiangpi ShengJi ointment group , moist burn cream group and vaseline group , each group had 10 rats and were given respective drugs for dressing changes .The wound repair and the expression of TGF -β1 in granula-tion tissue in every group were observed .Results The curing rate of wound and the expression rate of TGF -β1 in Xiangpi ShengJi ointment group on the 8th and 14th day were significantly higher , while wound edema scores were lower , wound heal-ing time was shorter than those in the other two groups (P<0.05), and on the 14th day, the indexes above including curing rate of curing rate , wound edema scores , wound healing time in moist burn cream group were better than that in vaseline group.Conclusion Xiangpi ShengJi ointment could obviously increase wound healing rate after anal fistula surgery , shorten wound healing time , and this mechanism may related with its regulation of the expression of TGF -β1 in wound tissue .%目的：探讨象皮生肌膏对肛瘘术后创面修复的作用机制。方法将30只SD大鼠肛瘘术后创面造模，随机分为象皮生肌膏组、湿润烧伤膏组和凡士林组，每组10只，分别给予相应药物创面换药。动态观察各组治疗后创面修复情况及肉芽组织中转化生长因子β1（ TGF－β1）的表达情况。结果象皮生肌膏组第8天、第14天创面愈合率及TGF－β1表达水平均明显高于其他2组（P均＜0．05），第14天创面愈合率湿润烧伤膏组高于凡士林组（P＜0.05）；创面水肿评分明显低于其他2组（P均＜0．05），而湿润烧伤膏组低于凡士林组（P＜0．05）；创面完全愈合时间明显短于其他2组（P均＜0．05），而湿润烧伤膏组短于凡士林组（P＜0．05）。结论象皮生肌膏可明显提高肛瘘术后创面愈合率，缩短创面愈合时间，其促进肛瘘术后创面愈合的作用机制可能与调节创面中TGF－β1表达有关。