Objective It is to investigate the addiction of benzodiazepine sedatives and non-benzodiazepine sedatives and their effect of withdrawal treatment .Methods 193 collected cases of chronic insomnia patients with long-term use of sedative drugs, there are 98 cases used benzodiazepine , and 95 cases used non-benzodiazepine.All the patients had histories of using sedatives more than half year , and were treated with drug withdrawal by the same integrated traditional Chinese and Western medicine treatment .The addictive situations and the effects of drug withdrawal therapy of the two groups were observed .Re-sults The total effective rate and the cure rate of the non-benzodiazepine group were significantly higher than those of the benzodiazepine group (all P<0.01);Most of the two groups of withdrawal symptoms were disappear;and the rate of rebound insomnia in the group with non-benzodiazepine was significantly lower than that in the group with benzodiazepine (P<0.05). Conclusion Both benzodiazepine and non-benzodiazepine can lead to patients with addiction , combined treatment of TCM and Western medicine can help to get rid of the sedative addiction of patients with insomnia , and non-benzodiazepine is easier than benzodiazepine to drop their addiction .%目的：探讨慢性失眠患者应用苯二氮类镇静剂和非苯二氮类镇静剂成瘾性及其戒断治疗情况。方法选择长期服用镇静剂的慢性失眠患者193例，其中苯二氮类镇静剂组98例，非苯二氮类镇静剂组95例，每例患者服用镇静剂均超过6个月，2组均采用相同的中西医结合综合方案进行药物戒断，观察2组患者的镇静剂成瘾性和药物戒断情况。结果非苯二氮类镇静剂组总有效率及痊愈率均显著高于苯二氮类镇静剂组（P均＜0．05）；2组治疗后戒断症状大部分消失，且非苯二氮类镇静剂组反跳性失眠率明显低于苯二氮类镇静剂组（P＜0．05）。结论苯二氮类和非苯二氮类镇静剂治疗失眠症均可导致患者出现成瘾性，中西医结合治疗有助于戒除失眠患者的镇静剂成瘾性，且非苯二氮类镇静剂较苯二氮类镇静剂容易戒除。
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