丹参酮ⅡA 磺酸钠联合氯吡格雷对冠心病心绞痛疗效及血管内皮功能的影响

摘要

Objective It is to explore the effect of TanshinoneIIA Sulfonic Sodium combined with Clopidogrel on coronaryheart disease and angina pectoris and vascular endothelium function .Methods 60 patients with coronary heart disease and anginapectoris were randomly divided into experimental group and control group , both the groups were given normal therapy , onthis basis the control group was treated with Clopidogrel , the experimental group was treated with TanshinoneIIA Sulfonic Sodi -um combined with Clopidogrel.The attack times and lasting time of angina pectoris and dosage needed of nitroglycerin beforeand after treatment were observed in both groups , and the levels of NO, ET and TXB2 were determined.Results The attacktimes and lasting time of angina pectoris and dosage needed of nitroglycerin, the levels of ET and TXB2 all decreased aftertreatment while that of NO increased in both groups compared with that before treatment , and the decrease or increase in experimentalgroup was more significant (P <0.05).The total effective rate in experimental group was obviously higher thanthat in control group (P <0.05).Conclusion TanshinoneIIA Sulfonic Sodium combined with Clopidogrel can promote coro -nary artery dilatation, improve vascular endothelium function in the treatment with coronary heart disease and angina pectoris ,the curative effect is good and it is worthy of popularization and application .%目的：探讨丹参酮ⅡA磺酸钠联合氯吡格雷对冠心病心绞痛疗效及血管内皮功能的影响。方法将冠心病心绞痛患者60例随机分为实验组和对照组，均给予常规治疗，对照组在此基础上联合氯吡格雷进行治疗，实验组在对照组治疗基础上加用丹参酮ⅡA磺酸钠进行治疗，观察2组治疗前后心绞痛发作次数、持续时间以及缓解所需硝酸甘油剂量，同时检测2组治疗前后血液内一氢化氮（ NO）、内皮素（ ET）及血栓素A2（ TXB2）水平。结果2组治疗后心绞痛发作次数、持续时间、心绞痛缓解所需硝酸甘油剂量均明显下降，且实验组下降更为显著，差异均有统计学意义（P均＜0．05）；2组治疗后ET、TXB2水平均明显下降，NO水平均明显上升，差异均有统计学意义（P均＜0．05），且实验组较对照组变化更显著（P均＜0．05）；实验组有效率明显高于对照组（P＜0．05）。结论丹参酮ⅡA磺酸钠联合氯吡格雷治疗冠心病心绞痛可以促进冠状动脉的扩张，改善血管内皮功能，具有良好的临床疗效，值得在临床进一步推广。