超敏C-反应蛋白和胰岛素敏感指数在儿童阻塞性睡眠呼吸暂停综合征中的变化

摘要

Objective To study the changes of C-reactive protein (hs-CRP) and insulin sensitivity index (ISI) in children with obstructive sleep apnea syndrome (OSAS). Methods From February 2014 to February 2011 in our hospital for diagnosis and treatment of snoring and sleep apnea, 102 cases of children as the research object. According to the disease 51 cases were divided into OSAS (observation group) and 51 cases of primary snoring (control group). Compared with the two groups of patients with sleep monitoring results, the hs-CRP, ISI and ISI levels in the two groups were analyzed, and the correlation between hs-CRP level and the level of sleep monitoring was analyzed. Results The levels of AHI in the observation group were significantly higher than those in the control group, the level of LSaO2 was significantly lower than that in the control group, the difference was statistically significant(P<0.05). The average heart rate in the two groups was not statistically significant (P>0.05). The hs-CRP level of the observation group was signifi-cantly higher than that of the control group, the difference was statistically significant (P<0.05). But the two groups in UA, TG, FPG, TC, LDL-C,INS and ISI, and other indicators of the level of comparison, the difference was not statistically significant (P>0.05). According to the analysis of Pearson, hs-CRP levels were negatively correlated with LSaO2, and there was no significant corre-lation between, BMI, AHI, INS and ISI. Conclusions The body in children with OSAS hsCRP levels rise, but insulin sensitive index without significant changes, clinical should this attention, and early intervention in the treatment, so as to avoid induced cardiovascular diseases.%目的 研究超敏C-反应蛋白(hypersensitive3 C-reactive protein,hs-CRP)和胰岛素敏感指数(Insulin sensitivi-ty index,ISI)在儿童阻塞性睡眠呼吸暂停综合征(Obstructive sleep apnea syndrome,OSAS)中的变化. 方法 选择2011年2月~2014年2月在我院接受诊治的打鼾及睡眠呼吸异常患儿102例作为研究对象. 根据疾病情况将患儿分成OSAS者51例(观察组)和原发性鼾症者51例(对照组). 对比两组患儿多导睡眠监测结果,两组患儿hs-CRP、ISI各相关指标及ISI水平,分析观察组患儿hs-CRP水平与睡眠监测各指标水平的相关性.结果 观察组的AHI水平显著高于对照组,LSaO2水平显著低于对照组,差异均有统计学意义(均P<0.05). 两组的平均心率相比,差异无统计学意义(P>0.05). 观察组的hs-CRP水平显著高于对照组,差异有统计学意义(P<0.05). 但两组在FPG、UA、TG、TC、LDL-C、INS及ISI等指标水平方面对比,差异均无统计学意义(均P>0.05). 根据Pearson法分析相关性可知,患儿hs-CRP水平与LSaO2呈负相关, 与平均心率、AHI、BMI、INS及ISI无明显的相关性. 结论 OSAS患儿机体的hsCRP水平上升,但胰岛素敏感指数无明显变化,临床上应对此加以关注,并进行尽早干预治疗,以免诱发心血管类病症.