比较两种不同促排卵方案对PCOS患者子宫内膜容受性的影响

摘要

Objective To observe and study two different programs on the effect of ovulation induc-tion in PCOS patients endometrial receptivity, and to explore a more effective ovulation induction programs to improve the clinical pregnancy rate. Methods From August 2014 to December 2014, at the hospital, 102 cases of polycystic ovary syndrome (polycystic ovary syndrome, PCOS) patients were randomly selected; the approval of the consent of family members of patients, depending on the patient treatment order, in accordance with 1:1 ratio, were randomly divided into two groups and the control group(51 patients in each group), in which the observation group were given FSH (Puli Kang) low-dose decrement program, the control group were given FSH (Puli Kang) low dose incremental program; and, two groups of patients ovulation, pregnancy outcome and follicle mid or late follicular phase endometrium HCG spiral artery flow spectrum and endometrial thickness, type of comparison was relevant data analysis. Results The ovulation rate of 86.84%, 44.74% cycle pregnancy rate was higher than that of(P<0.05); follicle mid or late follicular phase HCG day ob-servation group RI, PI, S/D were lower than the control group , and endometrial thickness was significantly increased compared with the control group (P<0.05); and the observation group en-dometrial type a type proportion (43.14%) was higher than that of (P<0.05). Conclusions Low-dose ovulation diminishing scheme can significantly improve PCOS patients endometrial receptivity, promote ovulation, improve clinical pregnancy, is an ideal ovulation induction program, worthy of promotion.%目的：观察和研究两种不同促排卵方案对PCOS患者子宫内膜容受性的影响，以期探索一种更加有效的促排卵方案以提高临床妊娠率。方法选取2014年8月~12月在本院102例多囊卵巢综合征患者，在征得患者家属同意后，根据患者就诊顺序，随机分为观察组和对照组各51例，观察组给予FSH （普丽康）低剂量递减方案，对照组给予FSH（普丽康）低剂量递增方案。对两组患者排卵、妊娠结局以及卵泡中期、卵泡晚期或HCG日子宫内膜螺旋动脉血流频谱及子宫内膜厚度、类型进行对比和相关数据的研究分析。结果观察组排卵率86．84％、周期妊娠率44．74％，高于对照组（P<0．05）；卵泡中期、卵泡晚期或HCG日，观察组RI、PI、S/D均低于对照组，而子宫内膜厚度较对照组明显增加（P<0．05）；且观察组子宫内膜类型中A型比例（43．14％）高于对照组（P<0．05）。结论低剂量促排卵递减方案能明显改善PCOS患者子宫内膜容受性，促进排卵，提高临床妊娠率，是一种较为理想的促排卵方案，值得推广。