目的:研究内南五味子的化学成分.方法:采用硅胶柱色谱,羟丙基葡聚糖凝胶 Sephadex LH-20、ODS及HPLC等多种色谱技术进行分离纯化,根据理化性质和波谱学方法鉴定化合物结构.结果:从内南五味子体积分数90%乙醇水提取物中分离得到了15个木脂素类化合物,分别为利卡灵A(1)、南五味子素(2)、异形南五味子丁素(3)、异形南五味子庚素(4)、8α-羟基松脂醇(5)、内南五味子素丙(6)、异形南五味子戊素(7)、扁核木醇(8)、阿里山五味子灵C(9)、苄基氧代南五味子醇(10)、松脂醇(11)、香豆木脂素(12)、川椒脂醇(13)、异形南五味子壬素(14)、二氢去氢二松柏醇(15).结论:化合物1、5、7、8、10～15是首次从内南五味子中分离得到.%Objective:To investigate the chemical constituents form stems of Kadsura interior.Methods:The com-pounds were isolated by various chromatographic techniques including silica gel column chromatography,Sephadex LH-20, ODS reverse phase column chromatography and reversed-phase HPLC.The structures were elucidated by physiochemical property and spectral analysis.Results:Fifteen compounds were isolated and identified as licarin A(1),kadsurin(2),het-eroclitin D(3),heteroclitin G(4),8a-hydroxypinoresinol(5),interiorin C(6),heteroclitin E(7),prinsepiol(8),schia-risanrin C(9),benzoyl oxokadsuranol(10),pinoresinol(11),coumarinlignan(12),piperitol(13),heteroclitin I(14)and dihydrodehydrodiconiferyl alcohol(15),Conclusion:Compounds 1,5,7,8,10-15 were isolated from K.interior for the first time.
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