Effects of Yupingfeng Polysaccharides on the Spleen Tissue Structure of Acute and Chronic Immunocompromised Mice

摘要

[Objectives]To study the protective and recovery effects of Yupingfeng polysaccharides(YPF-P)on spleen tissue structure of acute and chronic immunocompromised mice.[Methods]First,90 mice in the protective group were injected with cyclophosphamide to replicate the chronic immunosuppressive model,and observe the protective effects of different doses of YPF-P on the spleen;120 mice in the recovery group were injected with cyclophosphamide continuously to replicate the acute immune injury model,to observe the effects of YPF-P on spleen recovery.Besides,YPF-P positive control group was established to observe its effects on the spleen structure and function of normal mice.Testing indicators include spleen morphology and tissue structure,body mass,and spleen index.[Results]In the protective group and the recovery group,the spleen volume of the mice with different YPF-P doses increased significantly,and lymphocytes proliferated,showing obvious structural compensation and repair,and showing a dose-effect relationship.In the positive control group,the spleen function of the normal mice was significantly enhanced,and the spleen lymphoid tissue showed significant orderly proliferation.[Conclusions]Yupingfeng polysaccharides can effectively protect the function and structure of spleen,improve acute and chronic immune damage induced by cyclophosphamide,greatly promote the recovery of spleen structure and function after immune injury,and also can significant enhance the spleen structure and function of normal mice.