Research progress of Notch signaling pathway and biological behavior of tumor

摘要

cqvip:As an important signal transduction pathway between cells, Notch signaling pathway plays a very important role in cell recognition, proliferation, differentiation ,and apoptosis. At the same time, more and more related studies show that abnormal activation of Notch signaling pathway plays an important role in the occurrence and development of a variety of malignant tumors, and has become a hot topic in the field of tumor research. Instead of focusing on the relationship between Notch signaling pathway and various organ tumors or the relationship between Notch signaling pathway and tumor single regulatory factors, this paper focuses on the role of Notch signaling pathway by summing up and summarizing the role of the signal pathway. A series of biological behaviors of the tumor, such as angiogenesis, invasion, and metastasis, involved in Notch signaling pathway, are reviewed in this paper, as well as the recent advances in the regulation of tumor biological behavior, such as angiogenesis, invasion, metastasis and so on.