Correlation of peripheral blood NK cell content with tumor marker content and proliferation molecule expression in patients with non-small cell lung cancer

摘要

Objective:To study the correlation of peripheral blood NK cell content with tumor marker content and proliferation molecule expression in patients with non-small cell lung cancer (NSCLC).Methods: A total of 80 patients who were diagnosed with NSCLC in our hospital between June 2014 and October 2016 were selected as the NSCLC group of the research, and 96 healthy volunteers who received physical examination in our hospital during the same period were selected as the control group of the research. The peripheral blood NK cell content and serum tumor marker contents of two groups of subjects were determined, and the proliferation molecule expression levels in lung cancer focus tissue and focus tissue adjacent to carcinoma of NSCLC group were determined.Results:Peripheral blood NK cell content of NSCLC group was significantly lower than that of control group;serum CEA, CA125, Cyfra21-1 and HE4 contents were significantly higher than those of control group, and serum CEA, CA125, Cyfra21-1 and HE4 contents of NSCLC patients with high NK cell content were significantly lower than those of NSCLC patients with low NK cell content;c-myc, c-FLIP, Livin, Moesin and k-ras protein expression in lung cancer focus tissue were significantly higher than those in focus tissue adjacent to carcinoma, and c-myc, c-FLIP, Livin, Moesin and k-ras protein expression in lung cancer focus tissue with high NK cell content were significantly lower than those in lung cancer focus tissue with low NK cell content.Conclusion: Peripheral blood NK cell content significantly reduces in patients with NSCLC and is associated with the cancer cell proliferation activity.