STATs family expression in non-small cell lung cancer tissue and their potential target genes

摘要

Objective:To study the STATs family expression in non-small cell lung cancer tissue and the potential target genes of STATs.Methods: A total of 128 patients diagnosed with non-small cell lung cancer in our hospital between May 2013 and August 2016 were selected, lung cancer tissue and para-carcinoma tissue were collected to extract protein, and then enzyme linked immunosorbent assay kits were used to determine the expression of STATs as well as proliferation, apoptosis and angiogenesis-related genes.Results: STAT1 protein expression in non-small cell lung cancer tissue was significantly lower than that in para-carcinoma tissue, STAT3 and STAT5 protein expression were significantly higher than those in para-carcinoma tissue, and STAT2, STAT4 and STAT6 protein expression were not significantly different from those in para-carcinoma tissue;Bcl-2 and Bcl-xL protein expression in non-small cell lung cancer tissue with high STAT1 expression were significantly lower than those in non-small cell lung cancer tissue with low STAT1 expression while Caspase-2, Caspase-3 and Caspase-7 protein expression were significantly higher than those in non-small cell lung cancer tissue with low STAT1 expression;VEGF-A, VEGFR1, VEGFR2, FGF2 and FGFR1 protein expression in non-small cell lung cancer tissue with high STAT3 and STAT5 expression were significantly higher than those in non-small cell lung cancer tissue with low STAT3 and STAT5 expression. Conclusion:STAT1 is lowly expressed while STAT3 and STAT5 are highly expressed in non-small cell lung cancer tissue, the target genes of STAT1 are the proliferation and apoptosis genes, and the target genes of STAT3 and STAT5 are angiogenesis genes.