目的应用辛伐他汀干预治疗兔动脉粥样硬化，观测斑块组成结构及血管弹性变化情况，分析二者相关性。方法新西兰大白兔30只，随机分为正常对照组，腹主动脉球囊拉伤、高脂饲养构建的兔动脉粥样硬化模型组，使用辛伐他汀干预动脉粥样硬化治疗组；10周后观测各组实验对象腹主动脉斑块纤维帽厚度，并获得纤维帽的厚度与脂核横截面厚度的比值；应用血管回声跟踪技术评估实验对象的血管弹性。结果他汀干预治疗组斑块纤维帽厚度明显高于动脉粥样硬化模型组，而脂核厚度则相对较小；他汀干预治疗组血管弹性明显优于粥样硬化模型组，其差异有统计学意义（P<0.01）；帽/核比值与血管弹性系数呈负相关，与僵硬度呈负相关。结论辛伐他汀参与粥样硬化血管重构的整体过程，它可以抑制炎症、改善血管内皮功能及斑块组成结构。%Abstrac: Objeetive To study the effects of simvastin on the characterization of plaque and vascular elasticity in rabbits with atherosclerosis. Methods 30 New Zealand rabbits were randomly divided into three groups. The rabbits in control group were given basic food, and the rabbits in model group were given aortic endothelium balloon injury and high lipid diet, and simvastin were given to the treatment group. After 10 weeks, the ratio of thickness of fibrous cap and the lipid core areas were obtained by pathological observation, and vascular elasticity were estimated with echo-tracking. Results The rabbits in model group had the less weak thickness of fibrous cap and the greater areas of lipid core than the treatment group. And the vascular elasticity in simvastin treatment group were better than that of the model group(P<0.05). The ratio of thickness of fibrous cap and the lipid core areas were negativly related to pressure-strain elasticity modulus (Eρ) and the stiffness parameter (β). conclusion Simvastin participate in the everlasting atherosclerosis vascular remodeling, with inhibiting inflammation, improving vascular endothelial function and changing the characterization of plaque.
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