激活素A与心脏疾病关系的研究进展

摘要

Activin A is related to acute and chronic inflammation and can be used to predict the severity of the diseases.Activin A is also involved in the pathological process of fibrosis and apoptosis.In various dis-eases models,inhibition of activin A can attenuate inflammation ,fibrosis,apoptosis and mortality.The devel-opment and prognosis of heart diseases are tightly associated with inflammation,fibrosis and apoptosis,and activin A plays an important role in many heart diseases.Therefore activin A is regarded as a diagnostic and therapeutic tools in various heart diseases.%激活素A与急性及慢性炎症有关并可用于预测疾病的严重性，激活素 A也参与纤维化和凋亡等疾病的病理过程。在不同的疾病模型中，抑制激活素A能够减弱机体的炎症反应、逆转纤维化及降低病死率。心脏疾病的发生、发展及预后与炎症、纤维化和凋亡有密切关系，同时激活素A在很多心脏疾病中发挥重要作用。因此，激活素A已经成为诊断和治疗心脏疾病的一种工具。