脂联素与冠状动脉慢血流现象的关系

摘要

目的 探讨脂联素(APN)与冠状动脉慢血流现象(CSFP)之间的关系.方法 采用校正TIMI帧计数(CTFC)将入选病例分为两组:CSFP组35例及对照组35例.所有患者均于冠脉造影术中肝素抗凝管取血浆5ml,静置离心,-80℃冻存.用酶联免疫吸附法(ELISA)检测APN水平.常规化验血常规、肝、肾功、血脂、血凝全套、空腹血糖、糖化血红蛋白.分析APN与CSFP之间关系.结果 两组基线资料相当,冠脉CSFP组脂联素水平较对照组明显减低.结论 APN水平减低与CSFP密切相关.%Objective To discuss the correlation between adiponectin (APN) and coronary slow flow phenomenon (CSFP). Methods The selected cases were divided into CSFP group and control group by corrected TIMI frame count ( CTFC) with 35 patients in each group. Blood samples of 5 ml from these patients were obtained by heparin anticoagnulant tube during coronary angiography and were centrifuged after standing. Blood plasma was obtained and cryopreserved at - 80 ℃. APN level was detected by enzyme linked immunosorbent assay (ELISA). Examination was made in routine blood test, hepatic and renal function, blood fat, complete set tests of hemagglutination, fasting blood glucose and glycosylated hemoglobin. Correlation between APN and CSFP was analyzed. Results There was no difference in base line data between the two groups. Compared with the APN level of the control group, that of the CSFP group significantly decreased. The occurrence of CSFP increased among those patients with the decrease of plasma APN. Conclusion The decrease of APN level is closely related to CSFP.