荆芥内酯聚乳酸/聚乳酸聚乙二醇嵌段共聚物亚微粒胶囊剂制备及评价

摘要

Objective To study the preparation of ST - PLAPELA block copolymers capsules of submicron.Methods A modified method of emulsion - solvent evaporation was used to synthesize the drug - loaded submicron, which was added the antifreeze and dried by vacuum freeze - drying to form the drug powder.The size and dispersion of the powder were determined.Finally, the capsules were prepared by loading the drug powder into the shell.Results When lactose is twice the amount of the ST submicron and dried under vacuum for 48h, the form of ST submicron could be well kept.Conculsion This method of vacuum freeze - drying is suitable for the preparation of submicron capsules.%目的 制备与评价荆芥内酯聚乳酸/聚乳酸聚乙二醇嵌段共聚物(ST-PLA/PELA)亚微粒胶囊剂.方法 采用改良的乳化-溶剂挥发法制备载药亚微粒,加入抗冻剂进行冷冻干燥制得粉末装胶囊,并测定粒径及分散度.结果 加入乳糖量为荆芥内酯亚微粒质量的200%时,真空冷冻干燥48 h能较好地保持ST亚微粒的形态.结论 真空冷冻干燥工艺适宜制备亚微粒胶囊剂.