联合检测胸水INF-γ、ADA、CEA、CA125在良恶性胸腔积液鉴别诊断中的价值

摘要

Objective:To investigate the INF-γ、ADA、CEA、CA125 indicators of significance and diagnostic value for differentiating benign and malignant pleural effusion.Method:Collected 136 cases of patients with pleural effusion treated in our hospital,and divided into malignant group (n=75)and benign group(n=61).Compared results of INF-γ,ADA,CEA CA125 between two groups.Result:Malignancy tumor markers CEA and CA125 level of malignant group were significantly higher than those in benign group,while INF-γ,ADA expression level were significantly lower than that in benign group,with statistically significant difference(P<0.05).Joint detection can significantly improved the diagnostic sensitivity(93.3%). Conclusion:The joint detection of INF-γ,ADA,CEA,CA125 have important diagnostic significance and clinical value in differentiating benign and malignant pleural effusion.%　　目的：探讨胸水中INF-γ、ADA、CEA、CA125四项指标联合检测对于鉴别良恶性胸腔积液的意义和诊断价值。方法：收集2011年1月-2012年12月在笔者所在医院治疗的136例胸腔积液患者，经病理诊断分恶性组（n=75）和良性组（n=61），检测患者的胸水中CEA、CA125和INF-γ、ADA活性，并对检测结果进行比对分析。结果：恶性组肿瘤标志物CEA、CA125水平明显高于良性组， INF-γ、ADA表达水平明显低于良性组，差异具有统计学意义（P<0.05）。联合检测可显著提高诊断敏感性（93.3%）。结论：联合检测胸水中INF-γ、ADA、CEA、CA125四项指标，对鉴别良恶性胸腔积液有重要诊断意义和临床价值。