帕罗西汀联合认知行为治疗强迫性障碍的临床分析

摘要

Objective:To evaluate the curative effect and safety of paroxetine with cognitive behavior therapy. Method:60 obsessive-compulsive disorder patients with Yale-Brown obsessive-compulisive scale (Y-Bocs) score ≥16 were randomly divided into study group (treated with paroxetine and cognitive behavior therapy for 5 months) and control group (treated with paroxetine for 5 months),clinical effect was assessed with Yale-Brown obsessive-compulisive scale (Y-Bocs)and treatment emergent symptom scale (TESS),month 1,2,3,4 and 5.Result:Compared with the control group,the study group showed more Y-Bocs score decrease,although both groups Y-Bocs score decreased after treatment.The side effects of the two groups were fewer and lighter.Conclusion:Paroxetine with cognitive behavior therapy demonstrates more treatment effects than paroxetine only for patients with obsessive-compulsive disorder (OCD).%目的：评价帕罗西汀单药治疗及联合认知行为治疗强迫性障碍的疗效和安全性。方法：将60例强迫性障碍患者且Yale-Brown强迫量表（Y-Bocs）评分≥16分随机数字表法分为研究组（帕罗西汀联合认知行为治疗）和对照组（单用帕罗西汀治疗），每组各30例，治疗疗程为5个月。治疗前及治疗1、2、3、4、5个月时采用Y-Bocs评定疗效。结果：两组治疗后Y-Bocs评分较治疗前均显著降低，且研究组较对照组更为显著。两组不良反应少而轻微。结论：帕罗西汀联合认知行为治疗强迫性障碍较单用帕罗西汀疗效更好。