血清特异性抗体对乳糜泻疾病诊断价值的研究

摘要

目的：评价血清中抗组织转谷氨酰胺酶（tTG）抗体与抗麦胶蛋白抗体（AGA）在乳糜泻（Celiac Disease， CD）中的诊断价值。方法：对198例慢性腹泻患者进行血清特异性抗体检测，并结合胃肠镜及病理学检查进行疾病诊断。结果：在15例经胃肠镜和病理学确诊的CD患者中，Anti-tTG阳性14例，AGA阳性15例；在183例非CD患者中，tTG阳性5例，AGA阳性38例。结论：通过ROC曲线分析，血清抗组织转谷氨酰胺酶（tTG）抗体的阳性预测值PPV及阴性预测值NPV都较为理想，可作为CD筛查与诊断的重要指标。%Objective:To evaluate the value of Anti-tissue transglutaminase antibodies and Anti-gliadin antibodies detection on the diagnosis of celiac disease.Method:Serum tTG antibodies and AGA were measured in 198 chronic diarrhea patients.Endoscopic and pathological findings were compared.Result:Among 15 CD patients who were confirmed by endoscopic and pathological diagnosis, 14 cases were tTG antibodies positive and 15 cases were AGA positive.5 cases showed tTG antibodies and 28 cases showed AGA in 183 non-CD patients.Conclusion:ROC curve analysis indicated that positive predicted value(PPV)and negative predicted value(NPV)of tTG antibodies were higher than of AGA.It might be used as a useful mark for screening and diagnosis CD.