血浆骨桥蛋白水平变化对宫颈癌复发预测的价值

摘要

目的：分析宫颈癌患者治疗前后及复发后血浆骨桥蛋白（OPN）的变化，评价OPN在预测宫颈癌复发中的作用。方法：应用酶联免疫吸附（ELISA）法测定238例宫颈癌患者治疗前后及随访5年的血浆OPN水平，统计分析血浆OPN水平和临床指标及复发的关系。结果：在Ⅰb~Ⅱa期宫颈癌患者中，OPN表达水平与分化程度、转移程度有关（P<0.05），与年龄、临床期别、细胞类型无关（P>0.05）。且随着治疗，血浆OPN表达水平明显降低（P<0.05）。当宫颈癌复发时血浆OPN表达水平明显高于未复发者（P<0.05）。结论：血浆OPN表达水平与宫颈癌的发展和复发密切相关，有望成为宫颈癌的一个复发预测指标。%Objective:To investigate the change of plasma osteopontin (OPN) level before and after treatment in cervical cancer patients and in cervical cancer recurrence.Method:The plasma OPN levels of 238 cervical cancer patients before and after treatment were measured by ELISA and followed for up to 5 years. The relations of between plasma OPN level and clinical variables, recurrence were analyzed.Result:Plasma OPN levels was associated with differentiation degree and metastasis in patients with stage Ⅰb-Ⅱa cervical cancer(P<0.05)and not associated with age, clinical stage and pathological type(P>0.05). Plasma OPN expression level decreased obviously after treatment(P<0.05). When cervical cancer recurrence plasma OPN level was significantly higher than without recurrence(P<0.05). Conclusion:The evaluation of plasma level of OPN may be helpful to predict the recurrence of cervical cancer patients in advance.