Ezrin蛋白在头颈部肿瘤中的研究进展

摘要

Ezrin protein is ERM protein family(Ezrin,Radixin and Moesin) important member,in mediating cancer cell differentiation,proliferation,invasion and metastasis of malignant behavior plays an important role,and is multiple system malignant tumor occurrence and development of a key factor.Many studies have shown that the expression of Ezrin protein is significantly increased in multi-system malignancies and their clinical TNM staging and pathological grading are positively correlated at present.This suggests Ezrin protein diagnosis and prognosis of head and neck malignant tumor has important clinical value.%Ezrin蛋白是ERM蛋白家族（Ezrin，Radixin和Moesin）中的重要成员，在介导肿瘤细胞分化、增殖、侵袭及转移等恶性行为中发挥重要作用，是多系统恶性肿瘤发生、发展的一个关键因素。目前许多研究表明：头颈部恶性肿瘤中Ezrin蛋白的表达均显著增加，并且与其临床TNM分期及其病理分级呈正相关。这提示Ezrin蛋白对头颈部恶性肿瘤的诊断、判断预后具有重要的临床价值。