（1，3）-β-D葡聚糖检测联合CD4+T淋巴细胞计数对获得性免疫缺陷综合征合并侵袭性真菌病诊断的价值

摘要

目的：探讨分析（1，3）-β-D葡聚糖（BDG）检测（G试验）联合CD4+T淋巴细胞计数对于获得性免疫缺陷综合征（AIDS）合并侵袭性真菌病（IFD）的临床诊断价值。方法：选择本院收治的疑似合并IFD的AIDS患者59例作为研究对象，同时实施G试验及CD4+T淋巴细胞计数。按照IFD诊断标准，将患者分为IFD组31例及非IFD组28例。分析IFD组和非IFD组的CD4+T淋巴细胞计数结果及不同检测方法的阳性率检测结果。结果：IFD组CD4+T淋巴细胞计数显著低于非IFD组，两组比较差异有统计学意义（P<0.05）；IFD组患者的G试验结果显示阳性率为74.19%，联合诊断结果显示阳性率为90.32%；非IFD组患者G试验结果显示阳性率为17.86%，联合诊断结果显示阳性率为10.71%，两组比较差异均有统计学意义（P<0.05）。结论：G试验联合CD4+T淋巴细胞计数对于确诊AIDS合并IFD，具有极高的价值，值得推广应用。%Objective:To discuss the diagnosis significance of the detection of (1,3)-β-D glucan (BDG) and CD4+T lymphocyte count for the diagnosis of invasive fungal disease (IFD) in patients with Acquired Immune Deficiency Syndrome (AIDS).Method:Patients with AIDS suspected to suffer from IFD treated in our hospital were selected as the study objects,G test and CD4+T lymphocyte count were performed and detected simultaneously. According to the diagnosis standard of IFD, the patients were divided into IFD group of 31 cases and non-IFD group of 28 cases.G test for diagnosing IFD was analyzed for sensitivity and specificity. The results of CD4+T lymphocyte count and the positive rate of different detection methods of two groups were analyzed.Result:The CD4+T lymphocyte count in IFD group was significantly lower than that in non IFD group, the difference was statistically significant(P<0.05);G test results showed that the positive rate of IFD group was 74.19%, and the positive rate was 90.32%,G test results showed that the positive rate was 17.86% in the non IFD group,and the positive rate was 10.71%,the differences were statistically significant(P<0.05). Conclusion:G test combined CD4+T lymphocyte count has great value in diagnosing IFD with AIDS,it is worthy of generalizing and applying.