依达拉奉联合醒脑静注射液防治重型颅脑损伤急性期脑血管痉挛的临床研究

摘要

To explore the effect of combined treatment of Edaravone Injection and Xing naojing Injection to treat and prevent cerebral angio spasm in the acute stage of Gravis craniocerebral. Method: 61 patients with gravis craniocerebral injury (GCS 6-8 points) were randomly divided into control group (n=29) and treatment group(n=32) treated by routine methodes and combining Edaravone Injection and Xing naojing Injection based on the routine methodes respectively. Using the TCD to be the main mean to evaluate whether the cerebral angio spasm happened or not. The incidence rate of cerebral angio spasm, blood flow rate of the cerebral vessels, the incidence rate of traumatic cerebral infarction, ET-1 concentration of the and GCS were compared at the first day, 4th day, 7th day, 14th day after the patients in-hospital between the two groups. Result: The data were not significantly differences at the first day in-hospital between the two groups (P>0.05). But the datas in the treatment group at the 4th day,7th day,14th day in-hospital were significantly better than those in the control group (all P<0.05). Conclusion:Using the treatment of Edaravone Injection and Xing naojing Injection based on routine treatment can treat and prevent cerebral angio spasm in the acute stage of Gravis craniocerebral.%目的：探讨依达拉奉联合醒脑静注射液防治重型颅脑损伤急性期脑血管痉挛的效果。方法：将格拉斯哥昏迷（GCS）评分6-8分的颅脑损伤患者61例随机分为对照组（n＝29）和治疗组（n＝32），分别以常规方法和在常规治疗基础上加依达拉奉和醒脑静注射液治疗，以经颅多普勒超声（TCD）为主要评定脑血管痉挛的手段，比较两组患者入院第1、4、7、14 d 脑血管痉挛发生率、颅内血管血流速度、外伤性脑梗塞的发生率、脑脊液内皮素-1（ET-1）浓度及 GCS 变化。结果：入院第1 d 两组患者各项指标差异无统计学意义（P ＞0．05），治疗组第4、7、14 d 的各项指标均明显优于对照组（P ＜0．05）。结论：在常规治疗的基础上加用依达拉奉和醒脑静注射液能较好地防治重型颅脑损伤急性期的脑血管痉挛。