间充质干细胞影响肿瘤细胞增殖及其分子机理

摘要

问充质干细胞MSCs(mesenchymal stem cells)与肿瘤细胞间的相互作用是近年来肿瘤领域的研究热点之一.MSCs是一种多能干细胞,具有分化为成骨细胞、软骨细胞、脂肪细胞、纤维母细胞或肌肉细胞等多种间充质细胞的能力.MSCs在肿瘤细胞中表现出的归巢和转移能力为其成为潜在的抗肿瘤工具奠定了基础,MSCs转移到肿瘤细胞后参与重塑肿瘤微环境,并对其增殖、侵袭和转移等生物学行为产生重要影响.MSCs重塑肿瘤微环境后对肿瘤细胞的增殖究竟是促进还是抑制,相关文献报道有很大的争议.基于相关研究近况,主要综述骨髓间充质干细胞BMSCs (bone marrow derived mesenchymal stem eells)参与重塑肿瘤微环境对肿瘤细胞增殖的影响,并就已知的分子机理做一简要介绍.%The interaction of mesenchymal stem cells (MSCs) and tumor cells has become a hot point of cancer research. MSCs are multipotent stem cells that can differentiate into several mesenchymal cells, such as osteoblast, chondrocyte, adipocyte, fibroblast and muscle cells. The innate tropism of MSCs to tumors makes MSCs uniquely destined as a potential antitumor weapon. The homing mechanism of MSCs was involved in tumor microenvironment remolding and regulating proliferation and migration of tumor cells. However, there were still no consistant results reported. Here, the influence of bone marrow derived mesenchymal stem cells (BMSCs) on tumor proliferation and tumor environment remolding is reviewed, as well as a brief introduction of possible mechanisms towards the discrepancy.