多发性骨髓瘤相关microRNA的研究进展

摘要

microRNA (miRNA)是一种内源性非编码的单链小分子RNA,长度约19～24个核苷酸,通过靶向结合mRNA的3'非翻译区域(3 ' UTR)区域,抑制翻译或者降解靶标mRNA而调节基因的表达.miRNA参与一些重要的生理、病理学过程,包括细胞增殖、分化、生长和凋亡等.大量研究发现,miRNA与多发性骨髓瘤(multiple myeloma,MM)的发生、发展及诊断治疗等有着密切关系.深入探讨MM相关miRNA的调节机制和功能等,可为MM发病机制的研究及诊治提供新的思路.%microRNAs (miRNAs) are small single-strand non-coding RNAs of 19~24 nucleotides,which can inhibit translation or degrade the mRNA of target gene by binding to its 3' untranslated region (3' UTR).They have been shown to play the fundamental role in diverse physiologic and pathologic process,including cell proliferation,differentiation,growth and apoptosis,etc.A great number of studies had indicated a strong relationship between the miRNAs and the occurrence,development,diagnosis,treatment of mutiple myeloma (MM).Further studies on the regulation and function of MM associated miRNA may provide us new sights into MM pathogenesis and its diagnosis and treatment.