细胞重组：机遇与挑战

摘要

The ability to differentiate iPS cells into a wide range of lineages has created new opportunities in both clinical and research settings. Use of these cells for disease modeling and drug and toxicity screening can help overcome the limitations of current methods, enable construction of human models of complex diseases, and reveal important insights that can lead to a more personalized approach to medicine. Alongside their potential to reshape the research and clinical landscape, these remarkable cells have presented researchers with new questions to explore, challenges to address, and applications to discover.%人诱导性多能干（iPS）细胞能够分化成很多种类的祖细胞,这为临床和研究提供了新的机遇。这些细胞系可以用于疾病模型的建立、药物筛选以及毒性测试、帮助解决传统方法的局限性,也可以建立人类各种复杂疾病的细胞模型,对应用于更加个性化的医药研究领域也很有潜力。这些细胞系具有重新塑造临床研究领域的潜力,但是研究人员也面临着很多问题和挑战,也需要去发现新的应用。