缺血大鼠脑组织的太赫兹波吸收特性研究

摘要

为了探讨不同缺血时间的大鼠脑组织在0．4THz～0．95THz频段内的吸收特征，采用线栓法制备大鼠脑缺血模型，利用透射式太赫兹时域光谱仪对缺血大鼠脑组织进行检测，并进行了理论分析和实验验证，取得了缺血大鼠脑组织在0．4THz～0．95THz频段内吸收系数。结果表明，缺血时间不同的脑组织对太赫兹波呈现出各异的吸收特性，这是由缺血所致脑损伤级联反应中的兴奋性氨基酸、无氧呼吸所产生的乳酸等中间产物以及钙离子超载导致一氧化氮大量合成所造成的。这一结果对于研究缺血脑损伤的病理机制具有一定的指导作用和应用价值。%In order to explore the absorption features of rat brain tissue at different ischemia time , the model of middle cerebral artery occlusion was established and terahertz time-domain spectroscopy of ischemic rat brain tissue was measured .After theoretical analysis and experimental evaluation , terahertz absorption coefficient of ischemic brain tissue at different time in the frequency band from 0.4THz to 0.95THz was acquired.The results show that different absorption characteristics to terahertz wave at different time of ischemic brain tissue is due to intermediates , such as excitatory amino acids produced by ischemia brain injury cascade, lactic acid produced by anaerobic respiration , and large quantities of nitric oxide synthesis produced by calcium overload .The results will have an important role in studying the pathology mechanisms of ischemic brain injury and have a certain value in the biomedical field .