妊娠早期甲状腺功能异常与甲状腺自身抗体的相关性分析

摘要

Objective To investigate the correlation between abnormality of thyroid function with thyroid au-toantibody during early gestation .Methods A total of 1 375 early pregnant women ,treated in this hospital in 2013 , were selected and detected for serum levels of thyroid peroxidase antibody (TPOAb ) ,thyroglobulin antibody (TgAb) ,thyroid-stimulating hormone (TSH ) and free thyroxine (FT4) by using electrochemiluminescence assay . The distribution characteristics of TPOAb ,TgAb ,TSH and FT4 were analyzed .Results The simultaneously positive rate of TPOAb and TgAb was 6 .2% ,and the individual positive rates of TPOAb and TgAb were 7 .2% and 8 .1% . Incidence rate of subclinical hypothyroidism was 26 .9% ,of hypothyroxinemia was 1 .1% ,and of clinical hypothyroid-ism was 7 .6% .Levels of TSH ,FT4 ,TPOAb and TgAb were without statistical difference between subjects of differ-ent clinical groups(P>0 .05) .Conclusion Indicators of thyroid function could not fully reflect the thyroid function of early pregnant women .Combined detection of Indicators of thyroid function and thyroid autoantibody might be with greater clinical significance .%目的：探讨妊娠早期甲状腺功能异常与甲状腺自身抗体的相关性。方法选择2013年于本院就诊的妊娠早期妇女1375例，采用电化学发光法检测外周血甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TgAb）、促甲状腺激素（TSH）及游离甲状腺素（FT4）水平，分析妊娠早期 TPOAb、TgAb、TSH、FT4的分布特征。结果 TPOAb、TgAb同时阳性检出率为6．2％，其中TPOAb、TgAb阳性检出率分别为7．2％和8．1％。亚临床型甲状腺功能减退症检出率为26．9％，低甲状腺素血症检出率为1．1％，临床型甲状腺功能减退症检出率为7．6％。不同临床分组孕妇TSH、FT4、TPOAb、TgAb水平比较差异无统计学意义（P＞0．05）。结论妊娠早期甲状腺功能指标检测并不能完全反应甲状腺功能。妊娠早期甲状腺激素、甲状腺自身抗体联合检测临床意义更大。