目的：应用糖皮质激素治疗激素敏感型原发性肾病综合征（SSINS ）患儿蛋白尿，观察胆红素、血脂、尿蛋白水平的变化。方法遴选该院65例SSINS患儿作为治疗组，50例健康儿童作为健康对照组。治疗组采用泼尼松药物治疗，分别在治疗前，治疗后第2周、第4周、第6周、第8周、第10周、第12周检测6种生化指标：总胆固醇（TC）、三酰甘油（TG）、总胆红素（TBIL）、直接胆红素（DBIL）、清蛋白（ALB）以及24 h尿蛋白（24 hUpr）。结果治疗前，胆红素水平较健康对照组偏低，2组差异有统计学意义（P＜0．05），且经相关性分析，TBIL与24 hUpr水平呈负相关（t＝13．341，r＝－0．299）；治疗后，TC水平在第8周接近正常，ALB在第10恢复至正常，TG在第12周降至正常，但TBIL、DBIL和24 hUpr均在第2周恢复至正常水平。治疗前、后比较胆红素水平，2组差异有统计学意义（P＜0．05）。结论胆红素在SSINS临床早期治疗诊断及疾病预后评价中具有重要临床价值。%Objective To study the chang of total cholesterol ,triglyeride ,albumin ,bilirubin and urine protein in the patients with steroid‐sensitive idiopathic nephrotic syndrome in childrenMethods 65 patients with steroid‐sen‐sitive idiopathic nephrotic syndrome were chose as a group .A control group comprised 50 health children .After the treatment of prednisone ,the levels of total cholesterol ,triglyeride ,albumin ,bilirubin and 24 hour urinary protein were analysized at 2 week ,4 week ,6 week ,8 week ,10 week and 12 week .Results Compared with control group ,the bili‐rubin declined in the patients with steroid‐sensitive idiopathic nephrotic syndrome .There was significant statistical difference between them (P<0 .05) .After the treatment of prednisone ,the total bilirubin were negatively correlated with 24 hour urinary protein .The total cholesterol ,serum albumin and triglyeride decreased the level of the health children at 8 week ,10 week and 12 week ,respectively .But total bilirubin and direct bilirubin get recover at 2 week . Pre‐and posttreatment the total bilirubin were significant statistical difference (P< 0 .05) .Conclusion The level change of bilirubin can be applied to patients with idiopathic nephrotic syndrome for clinical diagnosis and assession and the change can be similar to 24 hour urinary protein .
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