低分子肝素钠联合硫酸镁对重度子痫前期患者血清高敏C反应蛋白和D-二聚体的影响分析

摘要

目的：探讨低分子肝素钠联合硫酸镁对重度子痫前期患者的血清高敏C反应蛋白（hs‐CRP）、D‐二聚体（D‐D）水平的影响。方法选择该院接诊的100例重度子痫前期患者，通过随机数表法分为观察组（50例）和对照组（50例），对照组采用硫酸镁治疗，观察组在硫酸镁治疗的基础上联合低分子肝素钠治疗。观察两组患者治疗前后血清hs‐CRP、D‐D、收缩压以及舒张压的变化，比较平均治疗时间、终止孕周时间、临床疗效及并发症的发生率。结果治疗后，观察组hs‐CRP ，D‐D水平均低于对照组，差异有统计学意义（P＜0．05）；观察组收缩压、舒张压水平低于对照组，差异具有统计学意义（P＜0．05）；观察组平均治疗时间，终止妊娠孕周时间均短于对照组，差异具有统计学意义（ P＜0．05）；观察组总有效率96．00％（48／50）高于对照组74．00％（37／50），并发症发生率6．00％（3／50）低于对照组24．00％（12／50），差异具有统计学意义（ P＜0．05）。结论低分子肝素钠联合硫酸镁可以有效降低重度子痫前期患者体内hs‐CRP和D‐D水平，抑制炎性反应，使新生儿的预后得到改善，值得在临床上应用推广。%Objective To investigate the effect of low molecular weight heparin sodium combined with Magnesium sulfate on se‐rum hypersensitive C‐reactive protein (hs‐CRP) ,D‐dimer (D‐D) in patients with severe preeclampsia .Methods A total of 100 pa‐tients with severe preeclampsia were selected in the hospital ,which were divided into observation group (50 cases) and control group (50 cases) randomly .And the control group was treated with magnesium sulfate ,the observation group was treated with low molecular weight heparin sodium combined with magnesium sulfate .The changes of hs‐CRP ,D‐D ,systolic blood pressure and dias‐tolic blood pressure were observed before and after treatment in the two groups .The average treatment time ,the time of termination of pregnancy ,the clinical efficacy and the incidence of complications were compared .Results After treatment ,hs‐CRP ,D‐D levels in the observation group were significantly lower than those in the control group (P< 0 .05) .Systolic blood pressure and diastolic blood pressure were also lower than those in control group ,there was statistically significant difference(P<0 .05) .Meanwhile ,the average treatment time of observation group and the time of termination of pregnancy were shorter than the control group ,and the difference was statistically significant (P<0 .05) .The total effective rate in the observation group [96 .00% (48/50)] was signifi‐cantly higher than that in the control group[74 .00% (37/50)](P<0 .05) ,and the incidence of complications [6 .00% (3/50)] was also significantly lower than that of the control group[24 .00% (12/50)](P<0 .05) .Conclusion Low molecular weight heparin so‐dium combined with magnesium sulfate can effectively reduce hs‐CRP and D‐D levels in patients with severe preeclampsia ,and in‐hibit the inflammatory response ,which could also improve the prognosis of newborns and be worthy of clinical application .