非洲绿猴在艾滋病研究中的应用进展

摘要

人类在人免疫缺陷病毒(human immunodeficiency virus,HIV-1)感染后,通常经过一段潜伏期,进展为艾滋病(acquired immunodeficiency syndromes,AIDS).非洲绿猴(African green monkeys,AGM)是SIV(simian immunodeficiency virus,SIV)的天然宿主,虽然体内的病毒水平与HIV感染者相似,但不表现出艾滋病症状.因此,探索AGM控制病毒复制和疾病进展的分子机制,可以很好地促进对HIV感染致病机理的认识和AIDS疫苗与治疗方法的研究.本文简要介绍AGM在艾滋病研究中的应用和最新研究进展,为艾滋病动物模型的研究提供更多参考.%Human infected with human immunodeficiency virus (HIV-1) always progress to AIDS after a variable period of latency. However, African green monkeys (AGM) with high levels of virus do not show any signs of AIDS after natural infection with simian immunodeficiency virus (SIV). This elicited interest of researchers to use AGM in studies on the cellular and molecular mechanisms to control virus replication and disease progression. In this paper, recent progresses in this field were briefly reviewed.