[目的]分析我院重症监护病房(ICU)患者病原菌的分布及耐药情况，为临床合理使用抗生素提供依据。[方法]对送检的863份标本的细菌分布及耐药性进行回顾性分析，归类总结。[结果]863份标本共检出552株细菌。革兰氏阴性杆菌对氨苄西林、头孢类耐药率较高，对环丙沙星、妥布霉素丁胺卡那耐药率较低；革兰氏阳性球菌除对万古霉素无耐药外，对青霉素、奎诺酮类耐药率较高；真菌耐药性较低。[结论]ICU患者感染严重，病原菌以革兰氏阴性杆菌为主,其次是革兰氏阳性球菌及真菌。应加强ICU感染病菌的鉴定及药敏试验，合理使用抗生素，避免耐药菌在医院传播及流行。%[Objective] To analyze the distribution of pathogens and drug resistance of the patients in our hospital's intensive care u-nit(ICU) ,in order to providing the clinical basis for the rational use ofantibiotics. [Methods] Analyzed 863 samples of bacteria distribution and drug resistance delivered. [Results] 552 samples of bacteria were detected intotal 863,including 437 Gram-negative bacilli, 62 fungi, 51 Gram-positive cocci. In the respect of .drug resistance, Gram-negative bacilli has higher rates of drug resistance to benzyl-an,cephalosporin and has lower rates of drug resistance to ciprofloxacin,amikacin,tobramycin. Gram-positive cocci has higher drug resistance to penicillin, quinolone except that has no drug resistance to vancomycin. Fungi has lower rates of drug resistance. [Conclusion] ICU patients are seriously infected and mainly of pathogens is Gram-negative bacilli, followed by Gram-positive cocci and fungi. Identification and drug sensitivity test of ICU bacteria infection should be strengthened, rationally using antibiotics, preventing the spread of resistant bacteria in hospitals.
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