银杏叶制剂合并西酞普兰治疗血管性抑郁的对照研究

摘要

[目的]探讨银杏叶制剂合并西酞普兰治疗血管性抑郁的疗效。[方法]将62例血管性抑郁患者随机分为研究组和治疗组。研究组32例，采用银杏叶制剂合并西酞普兰联合治疗，240mg/d，分3次口服；对照组30例，单用西酞普兰，20mg口服，1次/d。在治疗前和治疗后4周、8周、12周分别用Hamilton抑郁量表(HAMD)评分，根据Hamilton抑郁量表平均分和总有效率评定疗效。[结果]治疗8周后研究组HAMD评分低于对照组(P＜0.05)，治疗12周后研究组HAMD评分明显低于对照组(P＜0.01)。治疗12周后研究组总有效率高于对照组(P＜0.05)。[结论]银杏叶制剂合并西酞普兰治疗血管性抑郁的疗效优于单用西酞普兰。%[Objective] To investigate the efficacy of folium ginkgo preparation and citalopram combined treatment in vascular depression. [Methods] Patients with vascular depression (n=62) participated in our treatment study were randomly divided into folium ginkgo preparation in combination with citalopram groupCinvestigation group,n=32) and citalopram single group(contrast group,n = 30),change in depression mood was measured by the Hamilton depression scale (HAMD) .before 4 weeks,8 weeks and 12 weeks after treatment,the effect was evaluated according to the average point of the Hamilton depression scale (HAMD) and the over effective rate. [Results] The HAMD score of the investigation group was lower than the contrast group 8 weeks after treatment, the HAMD score of the investigation group was lower remarkably than the contrast group 12 weeks after treatment, the over effective rate of the investigation group was higher than the contrast group 12 weeks after treatment. [Conclusion] The efficacy of folium ginkgo preparation and citalopram combined treatment in vascular depression was better than citalopram single.