[Objective] To observe CT-guided percutaneous laser disc decompression(PLDD) united collagenase target dissolution treatment of lumbar disc hernation,as compared with the simple PLDD. [Methods] The study population comprised 36 subjects from October 2006 to October 2010 in hospital. They consisted of 2 groups. PLDD group comprising 16 patients; PLDD united collagenase dissolution treatment comprising 20 patients. Visual analogue scale (VAS) score and the Japanese Orthopaedics Association (JOA) score were used to evaluate the pre-therapy and the therapeutic effects at 1th day, 3th day, lth week, lth month and 2nd month after operation, of which with improved rate>50% was classified excellent and good rate. The SPSS software was used tor all statistical analyses. T test was used to compare the study between 2 groups. Statistical significance was assumed when a null hypothesis could be rejected at P>0.05. [Result] There was no difference in VAS score, JOA score, excellent and good rate, and complications between 2 groups pre-operation and post-operation, while difference in VAS score and JOA score among lth and 2nd months postoperanon. [Conclusion] PLDD united collagenase target dissolution treatment had been proved to be an effective and safe therapy for patients in lumbar disc herniation. There was no difference in short-term effect between groups; while PLDD united collagenase dissolution had much more high long-term effect than the simple PLDD.%[目的]观察在CT引导下经皮激光椎间盘减压术(Percutaneous Laser Disk Decompressuer,PLDD)联合胶原酶靶点溶解术治疗腰椎间盘突出症的临床效果及其安全性,并与单纯PLDD治疗效果相比较.[方法]将2006年10月至2010年10月本研究选择的36例腰椎间盘突出症患者,分为PLDD治疗组16例和PLDD联合胶原酶靶点溶解术治疗组20例.两组均在CT定位下行微创介入治疗.比较两组患者治疗前、术后3d、术后1周、术后1月及术后2月的VAS评分和JOA评分、疼痛缓解50％时间、并发症发生率.所有数据统计均采用SPSS软件处理,统计方法采用t检验,以P＜0.05判定为有显著性差异.[结果]PLDD组和PLDD+胶原酶靶点溶解术组两组治疗前、术后3d及术后1周的VAS评分JOA评分、疼痛缓解50％的时间、并发症发生率相比均无显著性差异.两组术后1月和术后2月的VAS评分JOA评分均有显著性差异.两组无并发症出现.[结论] PLDD和胶原酶靶点溶解术是治疗椎间盘突出症患者安全、有效的微创介入治疗方法；PLDD联合胶原酶靶点溶解术治疗腰椎间盘突出症的长期疗效(2月后)优于单纯的PLDD.
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