Objective To investigate the relationship between asymptomatic inflammatory prostatitis (AIP)and serum prostate specific antigen (PSA). Methods Data collection was conducted in the Medical Examination Centre of Fangchenggang First People's Hospital.During the physical examination,trained physi-cians administered a standard questionnaire,basic data including National Institutes of Health Chronic Prostati-tis Symptom Index (NIH-CPSI),demographic information (age,education,occupation,etc),history of dis-ease,and lifestyle risk factors (smoking,alcohol consumption,and physical activity),and health status were collected using a standardized questionnaire.A trained profession conducted the anthtopometric parameters measurements for the participants.8 h-fasting vein blood was drawn and then the biochemical indexes [PSA, triglyceride (TG),high density cholesterol-cholesterol (HDL-C),and fasting blood glucose]were meas-ured.The expressed prostatic secretions (EPS)were collected and then were smeared on a glass slide for counting the mean WBC count of EPS.According to the NIH-CPSI score,and presence of inflammation,the participants were divided into a NIH-IV prostatitis group and a healthy group. Results The mean value of serum PSA in the healthy group and the NIH-IV prostatitis group were 0.91 ng/ml and 1.27 ng/ml,the standard deviation was 0.79 ng/ml,and 1.52 ng/ml,there were statistically significant differences (P <0.001).In NIH-IV prostatitis group,the scores of age,TG,diastolic blood pressure (DBP),systolic blood pressure (SBP),hypertension,education status,physical activity were higher than those in the healthy group. NIH-IV prostatitis (WBC≥3+)group compared to healthy group,along with the elevated PSA the OR value was also increased,the OR value was 1.078,3.589,4.406,respectively.In PSAQ4,with the elevation of in-flammation the OR value also increased.Respectively in age,education status,dyslipidemia,diabetes,high blood pressure,BMI,smoking,drinking,physical activity,DBP and SBP as adjust variable,in NIH - IV prostatitis group and NIH-IV prostatitis (WBC≥3+)group,as PSA increased the OR value increased gradu-ally. Conclusion High levels of serum PSA is a potential risk factors for NIH-IV asymptomatic inflamma-tory prostatitis.The EPS WBC counts in patients with NIH-IV prostatitis is positively associated with serum PSA.%目的：探讨无症状炎症性前列腺炎与血清前列腺特异抗原（PSA）水平的关系。方法采用标准设计生活方式的调查问卷并结合健康体检，获得试验数据和初始研究队列，采集包括美国国立卫生院慢性前列腺炎症状指标（NIH-CPSI）总评分、社会人口学资料、生活方式、用药手术史等基本信息。由经统一培训合格的专业人员为调查对象进行人体学参数测量，采集禁食8 h 的空腹静脉血标本，对 PSA、甘油三酯、高密度脂蛋白胆固醇和空腹血糖等生化指标进行检测。对参与者行前列腺按摩取出前列腺液，利用玻片法计数前列腺液中白细胞的平均量，根据 NIH-CPSI 评分及有无炎症，分成Ⅳ型前列腺组与健康组。结果血清 PSA 水平在健康组和Ⅳ型前列腺炎组均值分别为0．91和1．27（ng/ml），标准差为0．79和1．52（ng/ml），差异有统计学意义（P ＜0．001）。年龄、甘油三酯、收缩压、舒张压、高血压、受教育程度、运动在Ⅳ型前列腺炎组大于健康组。Ⅳ型前列腺炎（WBC≥3＋）对比健康组，随着 PSA 递增 OR 值也是递增的，分别是1．078、3．589、4．406。在 PSAQ4中随着炎症的增加 OR 值也递增。分别加入年龄，教育水平、血脂异常、糖尿病、高血压、BMI、抽烟、饮酒、运动、舒张压、收缩压作为调整变量后Ⅳ型前列腺炎组及按白细胞分组Ⅳ型前列腺炎（WBC≥3＋）随着 PSA 增加 OR 值逐渐递增。结论高水平的血清 tPSA 水平，是Ⅳ型前列腺炎的一个风险。Ⅳ型前列腺炎病人前列腺液中白细胞数量与血清 PSA 水平呈正相关。
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